Genetically edited hepatic cells expressing the NTCP-S267F variant are resistant to hepatitis B virus infection

Genetically edited hepatic cells expressing the NTCP-S267F variant are resistant to hepatitis B virus infection

The sodium-dependent taurocholate co-transporting polypeptide (NTCP)-S267F variant is known to be associated with a reduced risk of hepatitis B virus (HBV) infection and disease progression. The NTCP-S267F variant displays diminished function in mediating HBV entry, but its function in HBV infection...

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Bibliographic Details
Main Authors: Takuro Uchida, Seung Bum Park, Tadashi Inuzuka, Min Zhang, Joselyn N. Allen, Kazuaki Chayama, T. Jake Liang
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
HBV
NTCP
S267F polymorphism
CRISPR base editing
stem cell-derived hepatocyte
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050121001741

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http://www.sciencedirect.com/science/article/pii/S2329050121001741

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