Oncolytic Herpes Simplex Virus Inhibits Pediatric Brain Tumor Migration and Invasion

Oncolytic Herpes Simplex Virus Inhibits Pediatric Brain Tumor Migration and Invasion

Pediatric high-grade glioma (pHGG) and diffuse intrinsic pontine glioma (DIPG) are invasive tumors with poor survival. Oncolytic virotherapy, initially devised as a direct cytotoxic treatment, is now also known to act via immune-mediated mechanisms. Here we investigate a previously unreported mechan...

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Bibliographic Details
Main Authors: Julia V. Cockle, Anke Brüning-Richardson, Karen J. Scott, Jill Thompson, Timothy Kottke, Ewan Morrison, Azam Ismail, Angel M. Carcaboso, Ailsa Rose, Peter Selby, Joe Conner, Susan Picton, Susan Short, Richard Vile, Alan Melcher, Elizabeth Ilett
Format: Article
Language:English
Published: Elsevier 2017-06-01
Series:Molecular Therapy: Oncolytics
Subjects:
oncolytic virus paediatric brain tumor invasion migration
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770517300190

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http://www.sciencedirect.com/science/article/pii/S2372770517300190

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