Pharmacological Blockade of the Adenosine A<sub>2B</sub> Receptor Is Protective of Proteinuria in Diabetic Rats, through Affecting Focal Adhesion Kinase Activation and the Adhesion Dynamics of Podocytes

Pharmacological Blockade of the Adenosine A<sub>2B</sub> Receptor Is Protective of Proteinuria in Diabetic Rats, through Affecting Focal Adhesion Kinase Activation and the Adhesion Dynamics of Podocytes

Induction of the adenosine receptor A<sub>2B</sub> (A<sub>2B</sub>AR) expression in diabetic glomeruli correlates with an increased abundance of its endogenous ligand adenosine and the progression of kidney dysfunction. Remarkably, A<sub>2B</sub>AR antagonism prot...

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Bibliographic Details
Main Authors: Pablo Mendoza-Soto, Claudia Jara, Ángelo Torres-Arévalo, Carlos Oyarzún, Gonzalo A. Mardones, Claudia Quezada-Monrás, Rody San Martín
Format: Article
Language:English
Published: MDPI AG 2024-05-01
Series:Cells
Subjects:
diabetic nephropathy
proteinuria
podocyte effacement
adenosine receptors
Online Access:https://www.mdpi.com/2073-4409/13/10/846

Internet

https://www.mdpi.com/2073-4409/13/10/846

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