Perilla frutescens Extracts Protects against Dextran Sulfate Sodium-Induced Murine Colitis: NF-κB, STAT3, and Nrf2 as Putative Targets

Perilla frutescens Extracts Protects against Dextran Sulfate Sodium-Induced Murine Colitis: NF-κB, STAT3, and Nrf2 as Putative Targets

Perilla frutescens is a culinary and medicinal herb which has a strong anti-inflammatory and antioxidative effects. In the present study, we investigated the effects of Perilla frutescens extract (PE) against dextran sulfate sodium (DSS)-induced mouse colitis, an animal model that mimics human infla...

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Bibliographic Details
Main Authors: Deung Dae Park, Hye-Won Yum, Xiancai Zhong, Seung Hyeon Kim, Seong Hoon Kim, Do-Hee Kim, Su-Jung Kim, Hye-Kyung Na, Atsuya Sato, Takehito Miura, Young-Joon Surh
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-08-01
Series:Frontiers in Pharmacology
Subjects:
colitis
dextran sulfate sodium
inflammatory bowel disease
Perilla frutescens
NF-κB
STAT3
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00482/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2017.00482/full

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