Matrix Effect of Diverse Biological Samples Extracted with Different Extraction Ratios on the Detection of β-<i>N</i>-Methylamino-<span style="font-variant: small-caps">L</span>-Alanine by Two Common LC-MS/MS Analysis Methods

Matrix Effect of Diverse Biological Samples Extracted with Different Extraction Ratios on the Detection of β-<i>N</i>-Methylamino-<span style="font-variant: small-caps">L</span>-Alanine by Two Common LC-MS/MS Analysis Methods

Neurotoxin β-<i>N</i>-methylamino-L-alanine (BMAA) is hypothesized as an important pathogenic factor for neurodegenerative diseases such as amyotrophic lateral sclerosis/parkinsonism-dementia complex (ALS-PDC). Comparative study on the accuracy of BMAA analyzed by the regular LC-MS/MS me...

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Bibliographic Details
Main Authors: Peng Zhao, Jiangbing Qiu, Aifeng Li, Guowang Yan, Min Li, Ying Ji
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Toxins
Subjects:
β-<i>N</i>-methylamino-L-alanine
extraction ratio
matrix effect
solid-phase extraction (SPE) purification
liquid chromatography-tandem mass spectrometry (LC-MS/MS)
Online Access:https://www.mdpi.com/2072-6651/14/6/387

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https://www.mdpi.com/2072-6651/14/6/387

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