Mycobacterium smegmatis strains genetically resistant to moxifloxacin emerge de novo from the moxifloxacin-surviving population containing high levels of superoxide, H2O2, hydroxyl radical, and Fe (II)

Mycobacterium smegmatis strains genetically resistant to moxifloxacin emerge de novo from the moxifloxacin-surviving population containing high levels of superoxide, H2O2, hydroxyl radical, and Fe (II)

Background: The antibiotic-exposed bacteria often contain the reactive oxygen species (ROS), hydroxyl radical, which inflicts genome-wide mutations, causing the de novo formation of antibiotic-resistant strains. Hydroxyl radical is generated by Fenton reaction of Fe (II) with the ROS, H2O2, which, i...

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Bibliographic Details
Main Authors: Avraneel Paul, Rashmi Ravindran Nair, Kishor Jakkala, Parthasarathi Ajitkumar
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2022-01-01
Series:International Journal of Mycobacteriology
Subjects:
antibiotic resistance
antibiotic-surviving population
hydrogen peroxide
hydroxyl radical
moxifloxacin
mycobacterium smegmatis
superoxide
Online Access:http://www.ijmyco.org/article.asp?issn=2212-5531;year=2022;volume=11;issue=2;spage=150;epage=158;aulast=Paul

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http://www.ijmyco.org/article.asp?issn=2212-5531;year=2022;volume=11;issue=2;spage=150;epage=158;aulast=Paul

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