Estimating cutoff values for diagnostic tests to achieve target specificity using extreme value theory

Abstract Background Rapidly developing tests for emerging diseases is critical for early disease monitoring. In the early stages of an epidemic, when low prevalences are expected, high specificity tests are desired to avoid numerous false positives. Selecting a cutoff to classify positive and negati...

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Bibliographic Details
Main Authors: Sierra Pugh, Bailey K. Fosdick, Mary Nehring, Emily N. Gallichotte, Sue VandeWoude, Ander Wilson
Format: Article
Language:English
Published: BMC 2024-02-01
Series:BMC Medical Research Methodology
Subjects:
Online Access:https://doi.org/10.1186/s12874-023-02139-5