Coffee as a dietary strategy to prevent SARS-CoV-2 infection
Abstract Background To date, most countries lifted the restriction requirement and coexisted with SARS-CoV-2. Thus, dietary behavior for preventing SARS-CoV-2 infection becomes an interesting issue on a daily basis. Coffee consumption is connected with reduced COVID-19 risk and correlated to COVID-1...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-11-01
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| Series: | Cell & Bioscience |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13578-023-01154-9 |
| _version_ | 1797556163001188352 |
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| author | Chen-Shiou Wu Yi-Chuan Li Shin-Lei Peng Chung-Yu Chen Hsiao-Fan Chen Po-Ren Hsueh Wei-Jan Wang Yen-Yi Liu Ciao-Ling Jiang Wei-Chao Chang Shao-Chun Wang Mien-Chie Hung |
| author_facet | Chen-Shiou Wu Yi-Chuan Li Shin-Lei Peng Chung-Yu Chen Hsiao-Fan Chen Po-Ren Hsueh Wei-Jan Wang Yen-Yi Liu Ciao-Ling Jiang Wei-Chao Chang Shao-Chun Wang Mien-Chie Hung |
| author_sort | Chen-Shiou Wu |
| collection | DOAJ |
| description | Abstract Background To date, most countries lifted the restriction requirement and coexisted with SARS-CoV-2. Thus, dietary behavior for preventing SARS-CoV-2 infection becomes an interesting issue on a daily basis. Coffee consumption is connected with reduced COVID-19 risk and correlated to COVID-19 severity. However, the mechanisms of coffee for the reduction of COVID-19 risk are still unclear. Results Here, we identified that coffee can inhibit multiple variants of the SARS-CoV-2 infection by restraining the binding of the SARS-CoV-2 spike protein to human angiotensin-converting enzyme 2 (ACE2), and reducing transmembrane serine protease 2 (TMPRSS2) and cathepsin L (CTSL) activity. Then, we used the method of "Here" (HRMS-exploring-recombination-examining) and found that isochlorogenic acid A, B, and C of coffee ingredients showed their potential to inhibit SARS-CoV-2 infection (inhibitory efficiency 43–54%). In addition, decaffeinated coffee still preserves inhibitory activity against SARS-CoV-2. Finally, in a human trial of 64 subjects, we identified that coffee consumption (approximately 1–2 cups/day) is sufficient to inhibit infection of multiple variants of SARS-CoV-2 entry, suggesting coffee could be a dietary strategy to prevent SARS-CoV2 infection. Conclusions This study verified moderate coffee consumption, including decaffeination, can provide a new guideline for the prevention of SARS-CoV-2. Based on the results, we also suggest a coffee-drinking plan for people to prevent infection in the post-COVID-19 era. |
| first_indexed | 2024-03-10T16:58:03Z |
| format | Article |
| id | doaj.art-6dbdceb921314a1688fa0c20a803c7c1 |
| institution | Directory Open Access Journal |
| issn | 2045-3701 |
| language | English |
| last_indexed | 2024-03-10T16:58:03Z |
| publishDate | 2023-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell & Bioscience |
| spelling | doaj.art-6dbdceb921314a1688fa0c20a803c7c12023-11-20T11:03:59ZengBMCCell & Bioscience2045-37012023-11-0113112010.1186/s13578-023-01154-9Coffee as a dietary strategy to prevent SARS-CoV-2 infectionChen-Shiou Wu0Yi-Chuan Li1Shin-Lei Peng2Chung-Yu Chen3Hsiao-Fan Chen4Po-Ren Hsueh5Wei-Jan Wang6Yen-Yi Liu7Ciao-Ling Jiang8Wei-Chao Chang9Shao-Chun Wang10Mien-Chie Hung11Graduate Institute of Biomedical Sciences, China Medical UniversityDepartment of Biological Science and Technology, China Medical UniversityDepartment of Biomedical Imaging and Radiological Science, China Medical UniversityResearch Center for Cancer Biology, China Medical UniversityGraduate Institute of Biomedical Sciences, China Medical UniversityDepartments of Laboratory Medicine and Internal Medicine, School of Medicine, China Medical University Hospital, China Medical University TaichungResearch Center for Cancer Biology, China Medical UniversityDepartment of Biology, National Changhua University of EducationGraduate Institute of Biomedical Sciences, China Medical UniversityCenter for Molecular Medicine, China Medical University Hospital, China Medical UniversityGraduate Institute of Biomedical Sciences, China Medical UniversityGraduate Institute of Biomedical Sciences, China Medical UniversityAbstract Background To date, most countries lifted the restriction requirement and coexisted with SARS-CoV-2. Thus, dietary behavior for preventing SARS-CoV-2 infection becomes an interesting issue on a daily basis. Coffee consumption is connected with reduced COVID-19 risk and correlated to COVID-19 severity. However, the mechanisms of coffee for the reduction of COVID-19 risk are still unclear. Results Here, we identified that coffee can inhibit multiple variants of the SARS-CoV-2 infection by restraining the binding of the SARS-CoV-2 spike protein to human angiotensin-converting enzyme 2 (ACE2), and reducing transmembrane serine protease 2 (TMPRSS2) and cathepsin L (CTSL) activity. Then, we used the method of "Here" (HRMS-exploring-recombination-examining) and found that isochlorogenic acid A, B, and C of coffee ingredients showed their potential to inhibit SARS-CoV-2 infection (inhibitory efficiency 43–54%). In addition, decaffeinated coffee still preserves inhibitory activity against SARS-CoV-2. Finally, in a human trial of 64 subjects, we identified that coffee consumption (approximately 1–2 cups/day) is sufficient to inhibit infection of multiple variants of SARS-CoV-2 entry, suggesting coffee could be a dietary strategy to prevent SARS-CoV2 infection. Conclusions This study verified moderate coffee consumption, including decaffeination, can provide a new guideline for the prevention of SARS-CoV-2. Based on the results, we also suggest a coffee-drinking plan for people to prevent infection in the post-COVID-19 era.https://doi.org/10.1186/s13578-023-01154-9CoffeeSARS-CoV-2ACE2TMPRSS2Cathepsin L |
| spellingShingle | Chen-Shiou Wu Yi-Chuan Li Shin-Lei Peng Chung-Yu Chen Hsiao-Fan Chen Po-Ren Hsueh Wei-Jan Wang Yen-Yi Liu Ciao-Ling Jiang Wei-Chao Chang Shao-Chun Wang Mien-Chie Hung Coffee as a dietary strategy to prevent SARS-CoV-2 infection Cell & Bioscience Coffee SARS-CoV-2 ACE2 TMPRSS2 Cathepsin L |
| title | Coffee as a dietary strategy to prevent SARS-CoV-2 infection |
| title_full | Coffee as a dietary strategy to prevent SARS-CoV-2 infection |
| title_fullStr | Coffee as a dietary strategy to prevent SARS-CoV-2 infection |
| title_full_unstemmed | Coffee as a dietary strategy to prevent SARS-CoV-2 infection |
| title_short | Coffee as a dietary strategy to prevent SARS-CoV-2 infection |
| title_sort | coffee as a dietary strategy to prevent sars cov 2 infection |
| topic | Coffee SARS-CoV-2 ACE2 TMPRSS2 Cathepsin L |
| url | https://doi.org/10.1186/s13578-023-01154-9 |
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