Lipoxins A4 and B4 inhibit glial cell activation via CXCR3 signaling in acute retinal neuroinflammation

Lipoxins A4 and B4 inhibit glial cell activation via CXCR3 signaling in acute retinal neuroinflammation

Abstract Lipoxins are small lipids that are potent endogenous mediators of systemic inflammation resolution in a variety of diseases. We previously reported that Lipoxins A4 and B4 (LXA4 and LXB4) have protective activities against neurodegenerative injury. Yet, lipoxin activities and downstream sig...

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Bibliographic Details
Main Authors: Izhar Livne-Bar, Shubham Maurya, Karsten Gronert, Jeremy M. Sivak
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Journal of Neuroinflammation
Subjects:
Lipoxins
Retina
Uveitis
Neuroinflammation
Inflammation resolution
Gliosis
Online Access:https://doi.org/10.1186/s12974-024-03010-0

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