Skeletal muscle p53‐depletion uncovers a mechanism of fuel usage suppression that enables efficient energy conservation

Skeletal muscle p53‐depletion uncovers a mechanism of fuel usage suppression that enables efficient energy conservation

Abstract Background The ability of skeletal muscle to respond adequately to changes in nutrient availability, known as metabolic flexibility, is essential for the maintenance of metabolic health and loss of flexibility contributes to the development of diabetes and obesity. The tumour suppressor pro...

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Bibliographic Details
Main Authors: Georgia Lenihan‐Geels, Francisco Garcia Carrizo, Marina Leer, Sabrina Gohlke, Moritz Oster, Sophie Pöhle‐Kronawitter, Christiane Ott, Alexandra Chadt, Isabel N. Reinisch, Markus Galhuber, Chen Li, Wenke Jonas, Markus Jähnert, Susanne Klaus, Hadi Al‐Hasani, Tilman Grune, Annette Schürmann, Tobias Madl, Andreas Prokesch, Michael Schupp, Tim J. Schulz
Format: Article
Language:English
Published: Wiley 2024-10-01
Series:Journal of Cachexia, Sarcopenia and Muscle
Subjects:
Energy conservation
p53
Metabolic efficiency
Metabolic homeostasis
Metabolism
Skeletal muscle
Online Access:https://doi.org/10.1002/jcsm.13529

Internet

https://doi.org/10.1002/jcsm.13529

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