B Cell Diversification Is Uncoupled from SAP-Mediated Selection Forces in Chronic Germinal Centers within Peyer’s Patches

Summary: Antibodies secreted within the intestinal tract provide protection from the invasion of microbes into the host tissues. Germinal center (GC) formation in lymph nodes and spleen strictly requires SLAM-associated protein (SAP)-mediated T cell functions; however, it is not known whether this m...

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Bibliographic Details
Main Authors: Adi Biram, Eitan Winter, Alice E. Denton, Irina Zaretsky, Bareket Dassa, Mats Bemark, Michelle A. Linterman, Gur Yaari, Ziv Shulman
Format: Article
Language:English
Published: Elsevier 2020-02-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720300474