Polyphyllin B inhibited STAT3/NCOA4 pathway and restored gut microbiota to ameliorate lung tissue injury in cigarette smoke-induced mice

Polyphyllin B inhibited STAT3/NCOA4 pathway and restored gut microbiota to ameliorate lung tissue injury in cigarette smoke-induced mice

Abstract Objective Smoking was a major risk factor for chronic obstructive pulmonary disease (COPD). This study plan to explore the mechanism of Polyphyllin B in lung injury induced by cigarette smoke (CSE) in COPD. Methods Network pharmacology and molecular docking were applied to analyze the poten...

Full description

Bibliographic Details
Main Authors: Qing Wang, Zhiyi He, Jinqi Zhu, Mengyun Hu, Liu Yang, Hongzhong Yang
Format: Article
Language:English
Published: BMC 2024-03-01
Series:BMC Biotechnology
Subjects:
Polyphyllin B
Cigarette smoke
COPD
Gut microbiota
STAT3/NCOA4 pathway
Online Access:https://doi.org/10.1186/s12896-024-00837-6

Internet

https://doi.org/10.1186/s12896-024-00837-6

Similar Items