Biological sex differences in renin angiotensin system enzymes ACE and ACE2 regulate normal tissue response to radiation injury

Biological sex differences in renin angiotensin system enzymes ACE and ACE2 regulate normal tissue response to radiation injury

Introduction: In experimental animal models, biological sex-differences in the manifestation and severity of normal tissue radiation injury have been well-documented. Previously we demonstrated male and female rats have differential and highly reproducible responses to high-dose partial body irradia...

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Bibliographic Details
Main Authors: Guru Prasad Sharma, Anne Frei, Brian Fish, Tracy Gasperetti, Dana Veley, Nathan Szalewski, Austen Nissen, Heather A. Himburg
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Physiology
Subjects:
ACE
ACE2
biological sex
radiation pneumonitis
renin angiotensin system
medical countermeasures
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2023.1191237/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2023.1191237/full

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