Integrating Immunologic Signaling Networks: The JAK/STAT Pathway in Colitis and Colitis-Associated Cancer

Integrating Immunologic Signaling Networks: The JAK/STAT Pathway in Colitis and Colitis-Associated Cancer

Cytokines are believed to be crucial mediators of chronic intestinal inflammation in inflammatory bowel diseases (IBD) such as Crohn’s disease (CD) and ulcerative colitis (UC). Many of these cytokines trigger cellular effects and functions through signaling via janus kinase (JAK) and signal transduc...

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Bibliographic Details
Main Authors: Sebastian Zundler, Markus F. Neurath
Format: Article
Language:English
Published: MDPI AG 2016-02-01
Series:Vaccines
Subjects:
inflammatory bowel disease
colitis-associated cancer
cytokines
janus kinase
signal transducer and activator of transcription
IL-6
Online Access:http://www.mdpi.com/2076-393X/4/1/5

Internet

http://www.mdpi.com/2076-393X/4/1/5

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