pH plays a role in the mode of action of trimethoprim on Escherichia coli.

Metabolomics-based approaches were applied to understand interactions of trimethoprim with Escherichia coli K-12 at sub-minimum inhibitory concentrations (MIC≈0.2, 0.03 and 0.003 mg L-1). Trimethoprim inhibits dihydrofolate reductase and thereby is an indirect inhibitor of nucleic acid synthesis. Du...

Full description

Bibliographic Details
Main Authors: Haitham AlRabiah, J William Allwood, Elon Correa, Yun Xu, Royston Goodacre
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6044521?pdf=render