Cancer‐associated fibroblasts nurture LGR5 marked liver tumor‐initiating cells and promote their tumor formation, growth, and metastasis

Cancer‐associated fibroblasts nurture LGR5 marked liver tumor‐initiating cells and promote their tumor formation, growth, and metastasis

Abstract Background & Aims In liver cancer, leucine‐rich repeat‐containing G‐protein coupled receptor 5 (LGR5) compartment represents an important tumor‐initiating cell (TIC) population and served as a potential therapeutic target. Cancer‐associated fibroblasts (CAFs) is a critical part of the t...

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Bibliographic Details
Main Authors: Mingna Zhang, Yiqiao Fang, Xia Fu, Jiaye Liu, Yang Liu, Zhounan Zhu, Yinyun Ni, Menglin Yao, Qiuwei Pan, Wanlu Cao, Zhihui Li, Chunyan Dong
Format: Article
Language:English
Published: Wiley 2023-09-01
Series:Cancer Medicine
Subjects:
cancer‐associated fibroblasts
diphtheria toxin receptor
leucine‐rich repeat‐containing G‐protein coupled receptor 5
liver cancer
tumor‐initiating cells
Online Access:https://doi.org/10.1002/cam4.6408

Internet

https://doi.org/10.1002/cam4.6408

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