CRAC Channel Controls the Differentiation of Pathogenic B Cells in Lupus Nephritis

CRAC Channel Controls the Differentiation of Pathogenic B Cells in Lupus Nephritis

Store-operated Ca2+ release-activated Ca2+ (CRAC) channel is the main Ca2+ influx pathway in lymphocytes and is essential for immune response. Lupus nephritis (LN) is an autoimmune disease characterized by the production of autoantibodies due to widespread loss of immune tolerance. In this study, RN...

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Bibliographic Details
Main Authors: Xue Li, Qin Zeng, Shuyi Wang, Mengyuan Li, Xionghui Chen, Yuefang Huang, Binfeng Chen, Mianjing Zhou, Yimei Lai, Chaohuan Guo, Siyuan Zhao, Hui Zhang, Niansheng Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Immunology
Subjects:
lupus nephritis
store-operated Ca2+ entry
Ca2+ release-activated Ca2+ channel
CaMK2
B-cell differentiation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.779560/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.779560/full

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