Counteracting poisoning with chemical warfare nerve agents

Phosphylation of the pivotal enzyme acetylcholinesterase (AChE) by nerve agents (NAs) leads to irreversible inhibition of the enzyme and accumulation of neurotransmitter acetylcholine, which induces cholinergic crisis, that is, overstimulation of muscarinic and nicotinic membrane receptors in the ce...

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Bibliographic Details
Main Authors: Hrvat Nikolina Maček, Kovarik Zrinka
Format: Article
Language:English
Published: Sciendo 2020-12-01
Series:Arhiv za Higijenu Rada i Toksikologiju
Subjects:
Online Access:https://doi.org/10.2478/aiht-2020-71-3459