Transcription-dependent DNA double-strand breaks and human disease

Transcription-dependent DNA double-strand breaks and human disease

Accumulation of DNA damage in resting cells is an emerging cause of human disease. We identified a mechanism of DNA double-strand break (DSB) formation in non-replicating cells, which strictly depends on transcription. These transcriptional DSBs arise from the twinned processing of R-loops and topoi...

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Bibliographic Details
Main Authors: Agnese Cristini, Natalia Gromak, Olivier Sordet
Format: Article
Language:English
Published: Taylor & Francis Group 2020-03-01
Series:Molecular & Cellular Oncology
Subjects:
dna double-strand break
dna repair
r-loop
rna/dna hybrid
senataxin
tdp1
xpf
neurodegenerative disease
cancer
topoisomerase i
transcription
Online Access:http://dx.doi.org/10.1080/23723556.2019.1691905

Internet

http://dx.doi.org/10.1080/23723556.2019.1691905

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