Investigation of HCAR2 antagonists as a potential strategy to modulate bovine leukocytes

Abstract Background Dairy cows experiencing ketosis after calving suffer greater disease incidence and are at greater risk of leaving the herd. In vitro administration of beta-hydroxybutyric acid (BHBA; the primary blood ketone) has inhibitory effects on the function of bovine leukocytes. BHBA is a...

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Bibliographic Details
Main Authors: Laman K. Mamedova, Kirby C. Krogstad, Paiton O. McDonald, Laxman Pokhrel, Duy H. Hua, Evan C. Titgemeyer, Barry J. Bradford
Format: Article
Language:English
Published: BMC 2024-03-01
Series:Journal of Animal Science and Biotechnology
Subjects:
Online Access:https://doi.org/10.1186/s40104-024-00999-5