Neutrophil Elastase Increases Vascular Permeability and Leukocyte Transmigration in Cultured Endothelial Cells and Obese Mice

Neutrophil Elastase Increases Vascular Permeability and Leukocyte Transmigration in Cultured Endothelial Cells and Obese Mice

Neutrophil elastase (NE) plays a pivotal role in inflammation. However, the mechanism underlying NE-mediated inflammation in obesity remains unclear. Here, we report that NE activates protease-activated receptor-2 (PAR2), stimulates actin filament (F-actin) formation, decreases intercellular junctio...

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Bibliographic Details
Main Authors: Chinchu Jagadan Ushakumari, Qiong L. Zhou, Yu-Hua Wang, Sijia Na, Michael C. Rigor, Cindy Y. Zhou, Max K. Kroll, Benjamin D. Lin, Zhen Y. Jiang
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Cells
Subjects:
neutrophil elastase
vascular endothelial injury
obesity
neutrophils
systemic inflammation
Online Access:https://www.mdpi.com/2073-4409/11/15/2288

Internet

https://www.mdpi.com/2073-4409/11/15/2288

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