Convergence of distinct signaling pathways on synaptic scaling to trigger rapid antidepressant action

Convergence of distinct signaling pathways on synaptic scaling to trigger rapid antidepressant action

Summary: Ketamine is a noncompetitive glutamatergic N-methyl-d-aspartate receptor (NMDAR) antagonist that exerts rapid antidepressant effects. Preclinical studies identify eukaryotic elongation factor 2 kinase (eEF2K) signaling as essential for the rapid antidepressant action of ketamine. Here, we c...

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Bibliographic Details
Main Authors: Kanzo Suzuki, Ji-Woon Kim, Elena Nosyreva, Ege T. Kavalali, Lisa M. Monteggia
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:Cell Reports
Subjects:
eEF2K
RARα
synaptic scaling
rapid antidepressant action
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721013917

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http://www.sciencedirect.com/science/article/pii/S2211124721013917

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