Benzene Derivatives from Ink Lead to False Positive Results in Neonatal Hyperphenylalaninemia Screening with Ninhydrin Fluorometric Method

Benzene Derivatives from Ink Lead to False Positive Results in Neonatal Hyperphenylalaninemia Screening with Ninhydrin Fluorometric Method

Ninhydrin-based fluorometric quantification of phenylalanine is one of the most widely used methods for hyperphenylalaninemia (HPA) screening in neonates due to its high sensitivity, high accuracy, and low cost. Here we report an increase of false positive cases in neonatal HPA screening with this m...

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Bibliographic Details
Main Authors: Shuren Feng, Joanne Mei, Lu Yang, Ping Luo, Xiaonan Wang, Yuan Wang, Jingyi Yao, Lan Cui, Lei Pan, Zefang Wang, Li Xin
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:International Journal of Neonatal Screening
Subjects:
neonatal screening
hyperphenylalaninemia (hpa), false-positive
ninhydrin fluorometric test
specimen collection devices
filter paper
newborns
dried blood spots
Online Access:https://www.mdpi.com/2409-515X/6/1/14

Internet

https://www.mdpi.com/2409-515X/6/1/14

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