Genome-wide DNA methylation risk scores for schizophrenia derived from blood and brain tissues further explain the genetic risk in patients stratified by polygenic risk scores for schizophrenia and bipolar disorder

Genome-wide DNA methylation risk scores for schizophrenia derived from blood and brain tissues further explain the genetic risk in patients stratified by polygenic risk scores for schizophrenia and bipolar disorder

Background Genetic and environmental factors contribute to the pathogenesis of schizophrenia (SZ) and bipolar disorder (BD). Among genetic risk groups stratified by combinations of Polygenic Risk Score (PRS) deciles for SZ, BD and SZ versus BD, genetic SZ risk groups had high SZ risk and prominent c...

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Bibliographic Details
Main Authors: Toshiki Shioiri, Midori Soda, Kazutaka Ohi, Mihoko Shimada, Daisuke Nishizawa, Daisuke Fujikane, Kentaro Takai, Ayumi Kuramitsu, Yukimasa Muto, Shunsuke Sugiyama, Junko Hasegawa, Kiyoyuki Kitaichi, Kazutaka Ikeda
Format: Article
Language:English
Published: BMJ Publishing Group 2024-01-01
Series:BMJ Mental Health
Online Access:https://ebmh.bmj.com/content/27/1/e300936.full

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https://ebmh.bmj.com/content/27/1/e300936.full

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