New 1,2,3-triazole/1,2,4-triazole hybrids linked to oxime moiety as nitric oxide donor selective COX-2, aromatase, B-RAFV600E and EGFR inhibitors celecoxib analogs: design, synthesis, anti-inflammatory/anti-proliferative activities, apoptosis and molecular modeling study

New 1,2,3-triazole/1,2,4-triazole hybrids linked to oxime moiety as nitric oxide donor selective COX-2, aromatase, B-RAFV600E and EGFR inhibitors celecoxib analogs: design, synthesis, anti-inflammatory/anti-proliferative activities, apoptosis and molecular modeling study

AbstractA new series of bis-triazole 19a-l was synthesised for the purpose of being hybrid molecules with both anti-inflammatory and anti-cancer activities and assessed for cell cycle arrest, NO release. Compounds 19c, 19f, 19h, 19 l exhibited COX-2 selectivity indexes in the range of 18.48 to 49.38...

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Bibliographic Details
Main Authors: Wael A. A. Fadaly, Mohamed T. M. Nemr, Taha H. Zidan, Fatma E. A. Mohamed, Marwa M. Abdelhakeem, Nour N. Abu Jayab, Hany A. Omar, Khaled R. A. Abdellatif
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
Aromatase inhibition
bis-Triazole
B-RAFV600E
inhibition
cyclooxygenase-2 inhibition
(EGFR) inhibition
Online Access:https://www.tandfonline.com/doi/10.1080/14756366.2023.2290461

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https://www.tandfonline.com/doi/10.1080/14756366.2023.2290461

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