Protective Functions of Liver X Receptor α in Established Vulnerable Plaques: Involvement of Regulating Endoplasmic Reticulum–Mediated Macrophage Apoptosis and Efferocytosis

Protective Functions of Liver X Receptor α in Established Vulnerable Plaques: Involvement of Regulating Endoplasmic Reticulum–Mediated Macrophage Apoptosis and Efferocytosis

Background Liver X receptor (LXR) belongs to the metabolic nuclear receptor superfamily, which plays a critical regulatory role in vascular physiology/pathology. However, effects of systemic LXR activation on established vulnerable plaques and the potential isotype‐specific role involved remain uncl...

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Bibliographic Details
Main Authors: Xinyu Che, Qingqing Xiao, Wei Song, Hengyuan Zhang, Beibei Sun, Na Geng, Zhenyu Tao, Qin Shao, Jun Pu
Format: Article
Language:English
Published: Wiley 2021-05-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
atherosclerosis
endoplasmic reticulum stress
liver X receptor α
macrophage
vulnerable plaque
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.120.018455

Internet

https://www.ahajournals.org/doi/10.1161/JAHA.120.018455

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