Chronic oxidative stress promotes H2AX protein degradation and enhances chemosensitivity in breast cancer patients

Chronic oxidative stress promotes H2AX protein degradation and enhances chemosensitivity in breast cancer patients

Abstract Anti‐cancer drugs often increase reactive oxygen species (ROS) and cause DNA damage. Here, we highlight a new cross talk between chronic oxidative stress and the histone variant H2AX, a key player in DNA repair. We observe that persistent accumulation of ROS, due to a deficient JunD‐/Nrf2‐a...

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Bibliographic Details
Main Authors: Tina Gruosso, Virginie Mieulet, Melissa Cardon, Brigitte Bourachot, Yann Kieffer, Flavien Devun, Thierry Dubois, Marie Dutreix, Anne Vincent‐Salomon, Kyle Malcolm Miller, Fatima Mechta‐Grigoriou
Format: Article
Language:English
Published: Springer Nature 2016-03-01
Series:EMBO Molecular Medicine
Subjects:
JUND
NRF2
RNF168
Triple‐Negative breast cancer
ubiquitination
Online Access:https://doi.org/10.15252/emmm.201505891

Internet

https://doi.org/10.15252/emmm.201505891

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