Mechanisms Underlying Mu Opioid Receptor Effects on Parallel Fiber-Purkinje Cell Synaptic Transmission in Mouse Cerebellar Cortex

Mechanisms Underlying Mu Opioid Receptor Effects on Parallel Fiber-Purkinje Cell Synaptic Transmission in Mouse Cerebellar Cortex

μ-opioid receptors (MOR) are widely expressed in the brain, varying in density in different areas. Activation of MORs underlies analgesia, euphoria, but may lead to tolerance, dependence, and ultimately opioid addiction. The Purkinje cell (PC) is the only efferent neuron in the cerebellar cortex and...

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Bibliographic Details
Main Authors: Yi Yang, Jin Bai, Jia-yue Sun, Ting Ye, Lu Zhang, Feng-ying Wu, Jun Nan, Yan Lan
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Synaptic Neuroscience
Subjects:
mu-opioid receptor
parallel fiber
cerebellar Purkinje cell
synaptic transmission
miniature postsynaptic currents
protein kinase A (PKA)
Online Access:https://www.frontiersin.org/articles/10.3389/fnsyn.2022.862704/full

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https://www.frontiersin.org/articles/10.3389/fnsyn.2022.862704/full

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