A novel validated UPLC method for quantitation of lopinavir and ritonavir in bulk drug and pharmaceutical formulation with its impurities

A novel validated UPLC method for quantitation of lopinavir and ritonavir in bulk drug and pharmaceutical formulation with its impurities

A simple gradient Ultra Performance liquid chromatographic method (UPLC) was developed for determination of lopinavir and ritonavir from its related impurities and assay for the first time. This method involves the use of a C18 (Acquity UPLC BEH C18, 50 × 2.1 mm, 1.7 µm) column thermostated at 30 oC...

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Bibliographic Details
Main Authors: Gnana Deepika Killi, Rama Krishna Maddinapudi, Sathis Kumar Dinakaran, Avasarala Harani
Format: Article
Language:English
Published: Universidade de São Paulo 2014-04-01
Series:Brazilian Journal of Pharmaceutical Sciences
Subjects:
Lopinavir/determinação
Ritonavir/determinação
Cromatografia Líquida de Ultra Eficiência/análise qualitativa
Cromatografia Líquida de Ultra Eficiência/análise quantitativa
Fármacos a granel/análise qualitativa
Formulações farmacêuticas/análise qualitativa
Formulações farmacêuticas/perfil de impureza
Fármacos a granel/perfil de impureza
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000200301&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000200301&lng=en&tlng=en

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