The unifying catalytic mechanism of the RING-between-RING E3 ubiquitin ligase family

The unifying catalytic mechanism of the RING-between-RING E3 ubiquitin ligase family

RBR E3 ubiquitin ligases utilise a 2-step catalytic mechanism previously defined for only few of the RBR family members. Here, the authors examine the poorly studied RBRs HOIL-1 and RNF216 to define general principles of RBR catalysis and regulation and identify specific functional differences.

Bibliographic Details
Main Authors: Xiangyi S. Wang, Thomas R. Cotton, Sarah J. Trevelyan, Lachlan W. Richardson, Wei Ting Lee, John Silke, Bernhard C. Lechtenberg
Format: Article
Language:English
Published: Nature Portfolio 2023-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-35871-z

Internet

https://doi.org/10.1038/s41467-023-35871-z

Similar Items