Development of an AAV-based model of tauopathy targeting retinal ganglion cells and the mouse visual pathway to study the role of microglia in Tau pathology

Development of an AAV-based model of tauopathy targeting retinal ganglion cells and the mouse visual pathway to study the role of microglia in Tau pathology

Tauopathy is a typical feature of Alzheimer's disease of major importance because it strongly correlates with the severity of cognitive deficits experienced by patients. During the pathology, it follows a characteristic spatiotemporal course which takes its origin in the transentorhinal cortex,...

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Bibliographic Details
Main Authors: Charlotte Duwat, Pauline Léal, Audrey Vautheny, Gwennaëlle Aurégan, Charlène Joséphine, Marie-Claude Gaillard, Anne-Sophie Hérard, Caroline Jan, Pauline Gipchtein, Julien Mitja, Stéphane Fouquet, Marie-Laure Niepon, Philippe Hantraye, Emmanuel Brouillet, Gilles Bonvento, Karine Cambon, Alexis-Pierre Bemelmans
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Neurobiology of Disease
Subjects:
Tauopathy
Animal model
AAV (adeno-associated virus)
Microglia
TREM2
Aging
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996123001304

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http://www.sciencedirect.com/science/article/pii/S0969996123001304

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