A Tailored Strategy to Crosslink the Aspartate Transcarbamoylase Domain of the Multienzymatic Protein CAD

A Tailored Strategy to Crosslink the Aspartate Transcarbamoylase Domain of the Multienzymatic Protein CAD

CAD is a 1.5 MDa hexameric protein with four enzymatic domains responsible for initiating de novo biosynthesis of pyrimidines nucleotides: glutaminase, carbamoyl phosphate synthetase, aspartate transcarbamoylase (ATC), and dihydroorotase. Despite its central metabolic role and implication in cancer...

Full description

Bibliographic Details
Main Authors: Francisco del Caño-Ochoa, Antonio Rubio-del-Campo, Santiago Ramón-Maiques
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Molecules
Subjects:
nucleotide metabolism
de novo pyrimidine biosynthesis
carbamoyl-phosphate synthetase
dihydroorotase
cysteine
disulfide bridge
Online Access:https://www.mdpi.com/1420-3049/28/2/660

Internet

https://www.mdpi.com/1420-3049/28/2/660

Similar Items