Polyelectrolyte-based solid dispersions for enhanced dissolution and pH-Independent controlled release of sildenafil citrate

Polyelectrolyte-based solid dispersions for enhanced dissolution and pH-Independent controlled release of sildenafil citrate

The aim of this study was to design a novel matrix tablet with enhanced dissolution and pH-independent controlled release of sildenafil citrate (SIL), a drug with pH-dependent solubility, by using solid dispersions (SDs) and polyelectrostatic interactions. SIL-loaded SDs were prepared using various...

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Bibliographic Details
Main Authors: Ju-Hyeong Woo, Hai V. Ngo, Hy D. Nguyen, Myung-Chul Gil, Chulhun Park, Jun-Bom Park, Jing-Hao Cui, Qing-Ri Cao, Beom-Jin Lee
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Heliyon
Subjects:
Sildenafil citrate
Soluplus®-based solid dispersion
Enhanced dissolution
Differently charged polymers
Polyelectrostatic interaction
Controlled release
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844023102994

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http://www.sciencedirect.com/science/article/pii/S2405844023102994

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