Polyelectrolyte-based solid dispersions for enhanced dissolution and pH-Independent controlled release of sildenafil citrate
The aim of this study was to design a novel matrix tablet with enhanced dissolution and pH-independent controlled release of sildenafil citrate (SIL), a drug with pH-dependent solubility, by using solid dispersions (SDs) and polyelectrostatic interactions. SIL-loaded SDs were prepared using various...
Main Authors: | Ju-Hyeong Woo, Hai V. Ngo, Hy D. Nguyen, Myung-Chul Gil, Chulhun Park, Jun-Bom Park, Jing-Hao Cui, Qing-Ri Cao, Beom-Jin Lee |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2023-12-01
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Series: | Heliyon |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023102994 |
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