Interactions of the protein tyrosine phosphatase PTPN3 with viral and cellular partners through its PDZ domain: insights into structural determinants and phosphatase activity

Interactions of the protein tyrosine phosphatase PTPN3 with viral and cellular partners through its PDZ domain: insights into structural determinants and phosphatase activity

The human protein tyrosine phosphatase non-receptor type 3 (PTPN3) is a phosphatase containing a PDZ (PSD-95/Dlg/ZO-1) domain that has been found to play both tumor-suppressive and tumor-promoting roles in various cancers, despite limited knowledge of its cellular partners and signaling functions. N...

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Bibliographic Details
Main Authors: Mariano Genera, Baptiste Colcombet-Cazenave, Anastasia Croitoru, Bertrand Raynal, Ariel Mechaly, Joël Caillet, Ahmed Haouz, Nicolas Wolff, Célia Caillet-Saguy
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Molecular Biosciences
Subjects:
protein tyrosine phosphatase PTPN3
X-ray crystallography
PDZ domains
PDZ-binding motif
enzyme kinetics
bioinformatics
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2023.1192621/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2023.1192621/full

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