Genipin prevents alpha-synuclein aggregation and toxicity by affecting endocytosis, metabolism and lipid storage

Genipin prevents alpha-synuclein aggregation and toxicity by affecting endocytosis, metabolism and lipid storage

In this work, the authors identify Genipin as a small iridoid able to prevent alpha-synuclein aggregation and toxicity by affecting endocytosis, metabolism and lipid storage.

Bibliographic Details
Main Authors: Rita Rosado-Ramos, Gonçalo M. Poças, Daniela Marques, Alexandre Foito, David M. Sevillano, Mafalda Lopes-da-Silva, Luís G. Gonçalves, Regina Menezes, Marcel Ottens, Derek Stewart, Alain Ibáñez de Opakua, Markus Zweckstetter, Miguel C. Seabra, César S. Mendes, Tiago Fleming Outeiro, Pedro M. Domingos, Cláudia N. Santos
Format: Article
Language:English
Published: Nature Portfolio 2023-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-37561-2

Internet

https://doi.org/10.1038/s41467-023-37561-2

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