Proanthocyanidin oligomers extract from hawthorn mediates cell cycle arrest, apoptosis, and lysosome vacuolation on HCT116 cells

Proanthocyanidin oligomers extract from hawthorn mediates cell cycle arrest, apoptosis, and lysosome vacuolation on HCT116 cells

In this study, Hawthorn oligomic procyanidins extracts (HPOE) were evaluated for their anticancer activity on colorectal cancer. Our results showed that HPOE arrested HCT116 cells cycle at G2/M phase through P53-Cyclin B pathway and promoted apoptosis partly via mitochondrial (Caspase 9-Caspase 3) a...

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Bibliographic Details
Main Authors: Ya-Sai Sun, Zi-Wei Wang, Zhe Gao, Wen Zhao, Kiran Thakur, Qian Zhong, Zhao-Jun Wei
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Current Research in Food Science
Subjects:
Hawthorn proanthocyanidin oligomers extract
Colon cancer
Cell cycle
Apoptosis
Vacuolation
Lysosomes
Online Access:http://www.sciencedirect.com/science/article/pii/S2665927122000818

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http://www.sciencedirect.com/science/article/pii/S2665927122000818

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