Proanthocyanidin oligomers extract from hawthorn mediates cell cycle arrest, apoptosis, and lysosome vacuolation on HCT116 cells
In this study, Hawthorn oligomic procyanidins extracts (HPOE) were evaluated for their anticancer activity on colorectal cancer. Our results showed that HPOE arrested HCT116 cells cycle at G2/M phase through P53-Cyclin B pathway and promoted apoptosis partly via mitochondrial (Caspase 9-Caspase 3) a...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | Current Research in Food Science |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2665927122000818 |
| _version_ | 1811188516805148672 |
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| author | Ya-Sai Sun Zi-Wei Wang Zhe Gao Wen Zhao Kiran Thakur Qian Zhong Zhao-Jun Wei |
| author_facet | Ya-Sai Sun Zi-Wei Wang Zhe Gao Wen Zhao Kiran Thakur Qian Zhong Zhao-Jun Wei |
| author_sort | Ya-Sai Sun |
| collection | DOAJ |
| description | In this study, Hawthorn oligomic procyanidins extracts (HPOE) were evaluated for their anticancer activity on colorectal cancer. Our results showed that HPOE arrested HCT116 cells cycle at G2/M phase through P53-Cyclin B pathway and promoted apoptosis partly via mitochondrial (Caspase 9-Caspase 3) and death receptor (Caspase 8-Caspase 3) pathways. Meanwhile, it was found that HPOE aggravated HCT116 cells death through lysosomal vacuolation, which was verified by inhibitor/activator of P53-ILC3 signaling pathway. Taken together, HPOE exerted anticancer effects which lays the foundation for the development of functional foods for clinical colon cancer patients. |
| first_indexed | 2024-04-11T14:21:13Z |
| format | Article |
| id | doaj.art-6e03af9df36543f38b3190902c0b1d24 |
| institution | Directory Open Access Journal |
| issn | 2665-9271 |
| language | English |
| last_indexed | 2024-04-11T14:21:13Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Current Research in Food Science |
| spelling | doaj.art-6e03af9df36543f38b3190902c0b1d242022-12-22T04:19:04ZengElsevierCurrent Research in Food Science2665-92712022-01-015904917Proanthocyanidin oligomers extract from hawthorn mediates cell cycle arrest, apoptosis, and lysosome vacuolation on HCT116 cellsYa-Sai Sun0Zi-Wei Wang1Zhe Gao2Wen Zhao3Kiran Thakur4Qian Zhong5Zhao-Jun Wei6College of Food Science and Technology, Agricultural University of Hebei, Baoding, 071001, PR China; School of Biological Science and Engineering, Ningxia Key Laboratory for the Development and Application of Microbial Resources in Extreme Environments, North Minzu University, Yinchuan, 750021, PR China; School of Food and Biological Engineering, Hefei University of Technology, Hefei, 230009, PR ChinaCollege of Food Science and Technology, Agricultural University of Hebei, Baoding, 071001, PR ChinaCollege of Food Science and Technology, Agricultural University of Hebei, Baoding, 071001, PR ChinaCollege of Food Science and Technology, Agricultural University of Hebei, Baoding, 071001, PR ChinaSchool of Biological Science and Engineering, Ningxia Key Laboratory for the Development and Application of Microbial Resources in Extreme Environments, North Minzu University, Yinchuan, 750021, PR China; School of Food and Biological Engineering, Hefei University of Technology, Hefei, 230009, PR ChinaSchool of Biological Science and Engineering, Ningxia Key Laboratory for the Development and Application of Microbial Resources in Extreme Environments, North Minzu University, Yinchuan, 750021, PR China; School of Food and Biological Engineering, Hefei University of Technology, Hefei, 230009, PR ChinaSchool of Biological Science and Engineering, Ningxia Key Laboratory for the Development and Application of Microbial Resources in Extreme Environments, North Minzu University, Yinchuan, 750021, PR China; School of Food and Biological Engineering, Hefei University of Technology, Hefei, 230009, PR China; Corresponding author. School of Biological Science and Engineering, North Minzu University, Yinchuan, 750021, PR China.In this study, Hawthorn oligomic procyanidins extracts (HPOE) were evaluated for their anticancer activity on colorectal cancer. Our results showed that HPOE arrested HCT116 cells cycle at G2/M phase through P53-Cyclin B pathway and promoted apoptosis partly via mitochondrial (Caspase 9-Caspase 3) and death receptor (Caspase 8-Caspase 3) pathways. Meanwhile, it was found that HPOE aggravated HCT116 cells death through lysosomal vacuolation, which was verified by inhibitor/activator of P53-ILC3 signaling pathway. Taken together, HPOE exerted anticancer effects which lays the foundation for the development of functional foods for clinical colon cancer patients.http://www.sciencedirect.com/science/article/pii/S2665927122000818Hawthorn proanthocyanidin oligomers extractColon cancerCell cycleApoptosisVacuolationLysosomes |
| spellingShingle | Ya-Sai Sun Zi-Wei Wang Zhe Gao Wen Zhao Kiran Thakur Qian Zhong Zhao-Jun Wei Proanthocyanidin oligomers extract from hawthorn mediates cell cycle arrest, apoptosis, and lysosome vacuolation on HCT116 cells Current Research in Food Science Hawthorn proanthocyanidin oligomers extract Colon cancer Cell cycle Apoptosis Vacuolation Lysosomes |
| title | Proanthocyanidin oligomers extract from hawthorn mediates cell cycle arrest, apoptosis, and lysosome vacuolation on HCT116 cells |
| title_full | Proanthocyanidin oligomers extract from hawthorn mediates cell cycle arrest, apoptosis, and lysosome vacuolation on HCT116 cells |
| title_fullStr | Proanthocyanidin oligomers extract from hawthorn mediates cell cycle arrest, apoptosis, and lysosome vacuolation on HCT116 cells |
| title_full_unstemmed | Proanthocyanidin oligomers extract from hawthorn mediates cell cycle arrest, apoptosis, and lysosome vacuolation on HCT116 cells |
| title_short | Proanthocyanidin oligomers extract from hawthorn mediates cell cycle arrest, apoptosis, and lysosome vacuolation on HCT116 cells |
| title_sort | proanthocyanidin oligomers extract from hawthorn mediates cell cycle arrest apoptosis and lysosome vacuolation on hct116 cells |
| topic | Hawthorn proanthocyanidin oligomers extract Colon cancer Cell cycle Apoptosis Vacuolation Lysosomes |
| url | http://www.sciencedirect.com/science/article/pii/S2665927122000818 |
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