Integrating Elastic Tensor and PC-SAFT Modeling with Systems-Based Pharma 4.0 Simulation, to Predict Process Operations and Product Specifications of Ternary Nanocrystalline Suspensions

Integrating Elastic Tensor and PC-SAFT Modeling with Systems-Based Pharma 4.0 Simulation, to Predict Process Operations and Product Specifications of Ternary Nanocrystalline Suspensions

Comminution of BCS II APIs below the 1 μm threshold followed by solidification of the obtained nanosuspensions improves their dissolution properties. The breakage process reveals new crystal faces, thus creating altered crystal habits of improved wettability, facilitated by the adsorption of stabili...

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Bibliographic Details
Main Authors: Andreas Ouranidis, Christina Davidopoulou, Kyriakos Kachrimanis
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Pharmaceutics
Subjects:
nanosuspensions
elastic tensor analysis
process and material design space
PC-SAFT
spray drying
stabilizer selection
Online Access:https://www.mdpi.com/1999-4923/13/11/1771

Internet

https://www.mdpi.com/1999-4923/13/11/1771

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