Distinctive mechanisms of epilepsy-causing mutants discovered by measuring S4 movement in KCNQ2 channels

Distinctive mechanisms of epilepsy-causing mutants discovered by measuring S4 movement in KCNQ2 channels

Neuronal KCNQ channels mediate the M-current, a key regulator of membrane excitability in the central and peripheral nervous systems. Mutations in KCNQ2 channels cause severe neurodevelopmental disorders, including epileptic encephalopathies. However, the impact that different mutations have on chan...

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Bibliographic Details
Main Authors: Michaela A Edmond, Andy Hinojo-Perez, Xiaoan Wu, Marta E Perez Rodriguez, Rene Barro-Soria
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-06-01
Series:eLife
Subjects:
KCNQ2
Kv7.2
epilepsy
voltage clamp fluorometry
cysteine accessibility
KCNQ gating scheme
Online Access:https://elifesciences.org/articles/77030

Internet

https://elifesciences.org/articles/77030

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