eSVD-DE: cohort-wide differential expression in single-cell RNA-seq data using exponential-family embeddings

Abstract Background Single-cell RNA-sequencing (scRNA) datasets are becoming increasingly popular in clinical and cohort studies, but there is a lack of methods to investigate differentially expressed (DE) genes among such datasets with numerous individuals. While numerous methods exist to find DE g...

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Bibliographic Details
Main Authors: Kevin Z. Lin, Yixuan Qiu, Kathryn Roeder
Format: Article
Language:English
Published: BMC 2024-03-01
Series:BMC Bioinformatics
Subjects:
Online Access:https://doi.org/10.1186/s12859-024-05724-7