Notch2 controls developmental fate choices between germinal center and marginal zone B cells upon immunization

Notch2 controls developmental fate choices between germinal center and marginal zone B cells upon immunization

Abstract Sustained Notch2 signals induce trans-differentiation of Follicular B (FoB) cells into Marginal Zone B (MZB) cells in mice, but the physiology underlying this differentiation pathway is still elusive. Here, we demonstrate that most B cells receive a basal Notch signal, which is intensified...

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Bibliographic Details
Main Authors: Tea Babushku, Markus Lechner, Stefanie Ehrenberg, Ursula Rambold, Marc Schmidt-Supprian, Andrew J. Yates, Sanket Rane, Ursula Zimber-Strobl, Lothar J. Strobl
Format: Article
Language:English
Published: Nature Portfolio 2024-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-46024-1

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https://doi.org/10.1038/s41467-024-46024-1

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