N-acetylcysteine dose-dependently improves the analgesic effect of acetaminophen on the rat hot plate test

Abstract Background Acetaminophen (APAP) induced hepatotoxicity is a clinically important problem. Up to now, interventive therapy with n-acetylcysteine (NAC) has been considered as a gold-standard treatment for APAP overdose. However, no study has focused on the efficacy of these drugs’ concurrent...

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Bibliographic Details
Main Authors: Samaneh Nakhaee, Mohammad Dastjerdi, Hesam Roumi, Omid Mehrpour, Khadijeh Farrokhfall
Format: Article
Language:English
Published: BMC 2021-01-01
Series:BMC Pharmacology and Toxicology
Subjects:
Online Access:https://doi.org/10.1186/s40360-020-00469-4