Structural Evaluation and Electrophysiological Effects of Some Kynurenic Acid Analogs

Structural Evaluation and Electrophysiological Effects of Some Kynurenic Acid Analogs

Kynurenic acid (KYNA), a metabolite of tryptophan, as an excitatory amino acid receptor antagonist is an effective neuroprotective agent in case of excitotoxicity, which is the hallmark of brain ischemia and several neurodegenerative processes. Therefore, kynurenine pathway, KYNA itself, and its der...

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Bibliographic Details
Main Authors: Evelin Fehér, István Szatmári, Tamás Dudás, Anna Zalatnai, Tamás Farkas, Bálint Lőrinczi, Ferenc Fülöp, László Vécsei, József Toldi
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Molecules
Subjects:
kynurenic acid
mannich reaction
neuroprotection
excitatory amino acid receptors
Online Access:https://www.mdpi.com/1420-3049/24/19/3502

Internet

https://www.mdpi.com/1420-3049/24/19/3502

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