Autoimmune response to AGE modified human DNA: Implications in type 1 diabetes mellitus

Autoimmune response to AGE modified human DNA: Implications in type 1 diabetes mellitus

Aims: Non-enzymatic glycation of DNA both in vivo and in vitro results in generation of free radicals, known as glycoxidation. Glycoxidation leads to structural perturbation of DNA resulting in generation of neo-antigenic epitopes having implication in autoimmune disorders like diabetes mellitus. In...

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Bibliographic Details
Main Authors: Saheem Ahmad, Moin Uddin, Safia Habib, Uzma Shahab, Khursheed Alam, Asif Ali
Format: Article
Language:English
Published: Elsevier 2014-09-01
Series:Journal of Clinical & Translational Endocrinology
Subjects:
DNA
MethylGlyoxal
Glycation
Auto-antibody
Diabetes mellitus
Online Access:http://www.sciencedirect.com/science/article/pii/S2214623714000167

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http://www.sciencedirect.com/science/article/pii/S2214623714000167

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