ADAM10 is involved in the oncogenic process and chemo-resistance of triple-negative breast cancer via regulating Notch1 signaling pathway, CD44 and PrPc

ADAM10 is involved in the oncogenic process and chemo-resistance of triple-negative breast cancer via regulating Notch1 signaling pathway, CD44 and PrPc

Abstract Background Triple-negative breast cancer (TNBC) is the most challenging breast cancer subtype to treat, because it is so aggressive with shorter survival. Chemotherapy remains the standard treatment due to the lack of specific and effective molecular targets. The aim of the present study is...

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Bibliographic Details
Main Authors: Yuanyuan Cheng, Lishuang Lin, Xiaoyan Li, Aiqi Lu, Chenjian Hou, Qian Wu, Xiaomu Hu, Zhongwen Zhou, Zhongqing Chen, Feng Tang
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Cancer Cell International
Subjects:
A disintegrin and metalloproteinase 10 (ADAM10)
Triple-negative breast cancer (TNBC)
Notch1 signaling
CD44
Cellular prion protein (PrPc)
Online Access:https://doi.org/10.1186/s12935-020-01727-5

Internet

https://doi.org/10.1186/s12935-020-01727-5

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