Nanoparticle-based DNA vaccine protects against SARS-CoV-2 variants in female preclinical models

Nanoparticle-based DNA vaccine protects against SARS-CoV-2 variants in female preclinical models

Abstract A safe and effective vaccine with long-term protection against SARS-CoV-2 variants of concern (VOCs) is a global health priority. Here, we develop lipid nanoparticles (LNPs) to provide safe and effective delivery of plasmid DNA (pDNA) and show protection against VOCs in female small animal...

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Bibliographic Details
Main Authors: Lays Cordeiro Guimaraes, Pedro Augusto Carvalho Costa, Sérgio Ricardo Aluotto Scalzo Júnior, Heloísa Athaydes Seabra Ferreira, Ana Carolina Soares Braga, Leonardo Camilo de Oliveira, Maria Marta Figueiredo, Sarah Shepherd, Alex Hamilton, Celso Martins Queiroz-Junior, Walison Nunes da Silva, Natália Jordana Alves da Silva, Marco Túllio Rodrigues Alves, Anderson Kenedy Santos, Kevin Kelton Santos de Faria, Fernanda Martins Marim, Heidge Fukumasu, Alexander Birbrair, Andréa Teixeira-Carvalho, Renato Santana de Aguiar, Michael J. Mitchell, Mauro Martins Teixeira, Vivian Vasconcelos Costa, Frederic Frezard, Pedro Pires Goulart Guimaraes
Format: Article
Language:English
Published: Nature Portfolio 2024-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-44830-1

Internet

https://doi.org/10.1038/s41467-024-44830-1

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