BMAL2 promotes eCIRP-induced macrophage endotoxin tolerance

BMAL2 promotes eCIRP-induced macrophage endotoxin tolerance

BackgroundThe disruption of the circadian clock is associated with inflammatory and immunological disorders. BMAL2, a critical circadian protein, forms a dimer with CLOCK, activating transcription. Extracellular cold-inducible RNA-binding protein (eCIRP), released during sepsis, can induce macrophag...

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Bibliographic Details
Main Authors: Mian Zhou, Monowar Aziz, Jingsong Li, Alok Jha, Gaifeng Ma, Atsushi Murao, Ping Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-06-01
Series:Frontiers in Immunology
Subjects:
eCIRP
macrophages
circadian
BMAL2
PD-L1
immune tolerance
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1426682/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1426682/full

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