Non-canonical NFKB signaling endows suppressive function through FOXP3-dependent regulatory T cell program

Non-canonical NFKB signaling endows suppressive function through FOXP3-dependent regulatory T cell program

Regulatory T cells (Tregs) play a central role in modulating adaptive immune responses in humans and mice. The precise biological role of non-canonical nuclear factor ‘κ-light-chain-enhancer’ of activated B cells (NFKB) signaling in human Tregs has yet to be fully elucidated. To gain insight into th...

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Bibliographic Details
Main Authors: Yohei Sato, Erika Osada, Yoshinobu Manome
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Heliyon
Subjects:
Regulatory T cells
NFKB signaling
CRISPR/Cas9
FOXP3
Suppressive function
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844023101198

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http://www.sciencedirect.com/science/article/pii/S2405844023101198

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