Loss of NOD2 in macrophages improves colitis and tumorigenesis in a lysozyme-dependent manner

Loss of NOD2 in macrophages improves colitis and tumorigenesis in a lysozyme-dependent manner

BackgroundCrohn’s disease (CD) is a complex and poorly understood myeloid-mediated disorder. Genetic variants with loss of function in the NOD2 gene confer an increased susceptibility to ileal CD. While Nod2 in myeloid cells may confer protection against T-cell mediated ileopathy, it remains unclear...

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Bibliographic Details
Main Authors: Camille Chauvin, Katarina Radulovic, Olivier Boulard, Myriam Delacre, Nadine Waldschmitt, Paul Régnier, Gauthier Legris, Clément Bouchez, Mohamed-Yassine Sleimi, Philip Rosenstiel, Guillaume Darrasse-Jèze, Mathias Chamaillard, Lionel F. Poulin
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Immunology
Subjects:
lysozyme
myeloid
colitis
cancer-associated colitis
NOD2
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1252979/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1252979/full

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